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ADVERTISEMENTS: Read this article to learn about the various physical, chemical and biological parameters of bioprocess that can be measured during fermentation/bioprocessing. There are a large number of physical, chemical and biological parameters that can be measured during fermentation/bioprocessing (Table 19.6) for data analysis and appropriate control. Chemical And Bioprocess Control Solution ManualBioprocess Control Sweden AB (BPC) is a privately held company based in Lund, Sweden. Bio-chemical and physico-chemical aspects are closely interrelated. For optimisation purposes, fermentation tests at laboratory scale are used to determine feedstock characteristics. Document and take photos of the parts and packaging. Chemical and bioprocess control pdf A bioprocess is a specific process that uses complete living cells or their components (e.g., bacteria, enzymes, chloroplasts) to obtain desired products. Control chemical dosing and dispersement with Cosasco’s retractable chemical injection/sampling tube assemblies. In systems with pressures up to 1500 psi a retractable method of injection is preferred. The injection/sampling tube can be inserted into the precise location. Various industrial applications, including bioprocess monitoring and control. Our online monitoring and control solutions have been designed to help make your job easier, increase your process knowledge and improve your process efficiency. YSI Life Sciences is here to support you. Our knowledgeable customer. Some special sensors have been developed to carry out measurements in the bioreactors. The basic requirement of all the sensors is that they must be sterilizable. The measurements of the parameters (listed in Table) can be done either directly in the bioreactor or in the laboratory. Important Parameters that can be measured during bioprocessing are. ADVERTISEMENTS: Ionic strength Biological Parameters Activities of specific enzymes Protein concentration Energetics (ATP concentration) DNA/RNA content pH measurement: There are pH electrodes that can withstand high temperature (sterilization) pressure and mechanical stresses, and yet measure the pH accurately. Combination electrodes (reference electrode, glass electrode) are being used. Chemical And Bioprocess Control Riggs Solution ManualIn fact, electrodes are also available for measuring several other inorganic ions. O 2 and CO 2 measurement: Oxygen electrodes and CO 2 electrodes can be used to measure O 2 and CO 2 concentrations respectively. The electrodes are amperometric in nature. They are however, susceptible for damage on sterilization. In a commonly used technique, O 2 and CO 2 respectively can be measured by the magnetic property of O 2 and the infrared absorption of CO 2. This can be done by using sensors. Use of Mass Spectrometer: The mass spectrometer is a versatile technique. It can be used to measure the concentrations of N 2, NH 3, ethanol and methanol simultaneously. In addition, mass spectrometer is also useful to obtain information on qualitative and quantitative exchange of O 2 and CO 2. Use of Gas-permeable Membranes: The measurement of dissolved gases, up to 8 simultaneously, can be done almost accurately by using gas-permeable membranes.
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